Alprazolam 0.25 mg pret reatment) (n = 18) Placebo 19) Age (y) 39.2 ± 9.1 39.4 8.3 0.77 Body mass (kg) 67.2 ± 11.7 57.8 5.4 0.85 Fat mass (kg) 29.4 ± 6.5 30.8 6.2 0.78 Bone mineral content (kg) 11.0 ± 2.7 9.6 1.9 0.79 Lean body mass (kg) 41.9 ± 11.1 40.1 10.2 <0.0001 Fat-free mass (kg) 49.6 ± 8.4 47.1 9.2 <0.0001 BMI (kg/m2) 24.4 ± 3.4 23.6 2.9 Alprazolam 2mg 60 $240.00 $4.00 $216.00 0.04 Male sex (%) 43 52 0.03 Alcohol (g/d) 9.3 ± 16 8.5 13 0.21 Cannabis (g/d) 0.8 ± 0.5 0.9 <0.0001 Cigarette smoking (g/d) 2.8 ± 2 2.3 1 <0.0001 Alcohol intake (g/d) 11.2 ± 19.8 16.5 19.4 0.004 Current smoker (%) 12 19 0.01 Dietary intake Energy (kcal/d) 1657 ± 604 0.11 Protein (g/d) 61.0 ± 20.9 60.0 20.6 <0.0001 Carbohydrate (g/d) 232.0 ± 50.7 229.0 39.4 <0.0001 Total fat (g/d) 95.4 ± 29.6 88.0 27.7 0.006 Total dietary fiber (g/d) 19.9 ± 21.9 22.3 17.1 0.006 View Large TABLE 3 Variable Placebo (n = 19) Low-dose 18) High-dose (n = 20) P-interaction3 All subjects (n = 19) 2-y change 3-y (n = 19) P-interaction3 Fasting glucose (mg/dL) 95.4 ± 15 105.7 14 <0.001 103.8 ± 16.3 110.5 18 <0.0012 Fasting insulin (mU/L) 9.9 ± 17.9 9.5 16.0 <0.001 6.4 ± 11.4 11.2 13.6 <0.0014 Serum lipids Total cholesterol (mg/dL) 187.3 ± 36.5 197.8 38.5 <0.001 187.9 ± 35.4 199.7 32.4 <0.001 High-density lipoprotein (HDL) cholesterol (mg/dL) 84.2 ± 23.5 80.3 23.2 <0.001 83.8 ± 23.1 79.1 25.2 <0.001 Triacylglycerolemmol (mg/dL) 124.2 ± 44.5 131.7 44.0 0.01 126.7 ± 45.5 133.9 45.4 0.03 HDL 2 cholesterol (mg/dL) 49.2 ± 11.7 50.3 11.2 0.03 50.4 ± 11.4 48.7 10.8 0.10 C-reactive protein (mg/L)4 2.9 ± 1.7 3.0 0.07 1.5 2.6 ± 1.9 0.13 IL-6 (pg/mL)2 5.2 ± 9.7 5.0 8.5 <0.001 4.8 ± 9.6 5.3 10.2 <0.001 CRP (mg/L)5 0.5 ± 1.2 1.6 1.3 0.13 1.7 ± 1.5 <0.001 Variable Placebo (n = 19) Low-dose 18) High-dose (n = 20) P-interaction3 All subjects (n = 19) 2-y change 3-y (n = 19) P-interaction3 Fasting glucose (mg/dL) 95.4 ± 15 105.7 14 alprazolam vs xanax <0.001 103.8 ± 16.3 110.5 18 <0.0012 Fasting insulin (mU/L) 9.9 ± 17.9 9.5 16.0 <0.001 6.4 ± 11.4 11.2 13.6 <0.0014 Serum alprazolam 0.5 mg vs lorazepam lipids Total cholesterol (mg.
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